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negative control compounds  (TargetMol)


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    TargetMol negative control compounds
    Negative Control Compounds, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/negative control compounds/product/TargetMol
    Average 94 stars, based on 12 article reviews
    negative control compounds - by Bioz Stars, 2026-04
    94/100 stars

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    Image Search Results


    (A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. VTX-217 (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.

    Journal: PLoS ONE

    Article Title: The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

    doi: 10.1371/journal.pone.0058164

    Figure Lengend Snippet: (A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. VTX-217 (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.

    Article Snippet: VTX-217 (a negative control with a similar core structure to other VTX compounds but with modifications to make inactive towards TLRs 7/8), VTX-744 (TLR8), VTX-087 (TLR8) and VTX-294 (TLR8) (VentiRx Pharmaceuticals, Inc., Seattle, WA, USA) were produced using a method of synthesis of substituted benzazepine derivatives .

    Techniques: Transfection, Activity Assay, Concentration Assay, Negative Control